Copper supplementation increases yeast life span under conditions requiring respiratory metabolism
نویسندگان
چکیده
منابع مشابه
Yeast replicative life span--the mitochondrial connection.
Mitochondria have been associated with aging in many experimental systems through the damaging action of reactive oxygen species. There is more, however, to the connection between mitochondria and Saccharomyces cerevisiae longevity and aging. Induction of the retrograde response, a pathway signaling mitochondrial dysfunction, results in the extension of life span and postponement of the manifes...
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BACKGROUND Oxidative stress is a probable cause of aging and associated diseases. Reactive oxygen species (ROS) originate mainly from endogenous sources, namely the mitochondria. METHODOLOGY/PRINCIPAL FINDINGS We analyzed the effect of aerobic metabolism on oxidative damage in Schizosaccharomyces pombe by global mapping of those genes that are required for growth on both respiratory-proficien...
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A model for replicative life span extension by calorie restriction (CR) in yeast has been proposed whereby reduced glucose in the growth medium leads to activation of the NAD+-dependent histone deacetylase Sir2. One mechanism proposed for this putative activation of Sir2 is that CR enhances the rate of respiration, in turn leading to altered levels of NAD+ or NADH, and ultimately resulting in e...
متن کاملIncreased Life Span due to Calorie Restriction in Respiratory-Deficient Yeast
Su-Ju Lin, Leonard Guarente The Kaeberlein et al. paper in the November 2005 issue of PLoS Genetics [1] claimed that calorie restriction (CR) in yeast does not require respiration to extend life span of mother cells. This claim challenges our earlier finding that deleting CYT1 (encoding cytochrome c1) prevented CR-associated longevity [2]. However, there is a fundamental difference in the two e...
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BACKGROUND Viability in a non dividing state is referred to as chronological life span (CLS). Most grape juice fermentation happens when Saccharomyces cerevisiae yeast cells have stopped dividing; therefore, CLS is an important factor toward winemaking success. RESULTS We have studied both the physical and chemical determinants influencing yeast CLS. Low pH and heat shorten the maximum wine y...
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ژورنال
عنوان ژورنال: Mechanisms of Ageing and Development
سال: 2007
ISSN: 0047-6374
DOI: 10.1016/j.mad.2006.10.003